Emphysema due to smoking tends to cause bulla formation in the upper lobes, whereas if it is due to
Emphysema due to smoking tends to cause bulla formation in the upper lobes, whereas if it is due to an inherited a1-antitrypsin deficiency, it tends to occur in the lower lobes. Smoke rises. The two guys at the bottom are wearing jeans because, y'know, it’s a genetic condition. -- source link
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